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Autoren:
Mayerhofer, Michael; Bencini, V.; Sammer, Matthias; Dollinger, Günther 
Dokumenttyp:
Zeitschriftenartikel / Journal Article 
Titel:
A carbon minibeam irradiation facility concept 
Zeitschrift:
Journal of Physics: Conference Series 
Jahrgang:
2420 
Jahr:
2023 
Seiten von - bis:
012097 
Sprache:
Englisch 
Abstract:
In minibeam therapy, the sparing of deep-seated normal tissue is limited by transverse beam spread caused by small-angle scattering. Contrary to proton minibeams, helium or carbon minibeams experience less deflection, which potentially reduces side effects. To verify this potential, an irradiation facility for preclinical and clinical studies is needed. This manuscript presents a concept for a carbon minibeam irradiation facility based on a LINAC design for conventional carbon therapy. A quadrupole triplet focuses the LINAC beam to submillimeter minibeams. A scanning and a dosimetry unit are provided to move the minibeam over the target and monitor the applied dose. The beamline was optimized by TRAVEL simulations. The interaction between beam and these components and the resulting beam parameters at the focal plane is evaluated by TOPAS simulations. A transverse beamwidth of < 100 μm (sigma) and a peak-to-valley (energy) dose ratio of > 1000 results for carbon energies of 100 MeV/u and 430 MeV/u (∼ 3 cm and 30 cm range in water) whereby the average beam current is ∼ 30 nA. Therefore, the presented irradiation facility exceeds the requirements for hadron minibeam therapy. 
Article-ID:
012097 
Fakultät:
Fakultät für Luft- und Raumfahrttechnik 
Institut:
LRT 2 - Institut für Angewandte Physik und Messtechnik 
Professur:
Dollinger, Günther 
Open Access ja oder nein?:
Ja / Yes 
Art der OA-Lizenz:
CC BY 3.0