The local temperature increase induced by ion energy deposition in tissue creates an "ionoacoustic" ultrasound signal, particularly at the dose maximum (Bragg peak). This signal may be used for range verification in ion beam therapy in the future, which is still an important challenge for this irradiation modality. This approach has recently been revisited by several groups in simulations, and by our group in simulations and also in proof-of-principle experiments with pulsed 20 MeV proton beams. Here we present new simulations and first measurements of the ionoacoustic signal produced in water by proton beams accelerated up to energies of 227 MeV at a clinical synchrocyclotron.    «

The local temperature increase induced by ion energy deposition in tissue creates an "ionoacoustic" ultrasound signal, particularly at the dose maximum (Bragg peak). This signal may be used for range verification in ion beam therapy in the future, which is still an important challenge for this irradiation modality. This approach has recently been revisited by several groups in simulations, and by our group in simulations and also in proof-of-principle experiments with pulsed 20 MeV proton beams....    »